Signaling Networks and Cell Cycle Control : The Molecular Basis of Cancer and Other Diseases (Cancer Drug Discovery and Development, 5)

von J. Silvio Gutkind Kategorie: Zellbiologie ISBN: 089603710X Kommentar abgeben

From Book News, Inc. Summarizes recent knowledge in the field and describes the effort to design and synthesize inhibiting molecules and to evaluate their biochemical and biological activities. Reviews relevant cell surface receptors, their ligands, and their downstream pathways, and examines the latest findings on components of novel signaling networks which control the activity of nuclear transcription factors and cell-cycle- regulatory molecules. Emphasis is on the most likely molecular targets for therapeutic intervention. The editor is affiliated with the National Institute of Dental and Craniofacial Research.Book News, Inc.®, Portland, OR

Synopsis In recent years, following an explosion in the knowledge of how cell surface receptors transmit signals to the nucleus, it has been discovered that a unique group of signalling molecules link each class of receptors to a variety of newly-discovered kinase cascades. This recent identification of key signalling and cell-regulating molecules has provided a golden opportunity in the search for novel targets for therapeutic intervention in disease. This text describes up-to-date knowledge on...