Parkinson's Disease: Methods & Protocols
|von Maral M. Mouradian|
Synopsis The application of molecular biological methodologies in the study of Parkinson's Disease has had a major impact in recent years. This work provides detailed molecular methodologies that are being used in the studies of Parkinson's Disease, including those used to advance our understanding of the etiologies and pathogenesis of neurodegeneration. The book is divided into four parts, the first of which covers genetic studies of the two established gene defects known to cause Parkinsonism, mainly the a-synuclein gene which results in autosomal dominant disease, and deletions or point mutations in the Parkin gene, which lead to autosomal recessive disease. Part two covers molecular pathogenic studies, including recent biochemical hypotheses and findings thought to be important in the death of nigral dopaminergic neurons. Part three covers the molecular aspects of basal ganglia function, while the final part, molecular therapies, describes experimental treatment approaches that have been tested, including intracerebral delivery of trophic factors, and the use of neural stem cells.
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