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Modern Cryo-Technology and Future Cryobanking

10.10.2005 - (idw) Fraunhofer-Institut für Biomedizinische Technik IBMT

The Fraunhofer Institute for Biomedical Engineering (IBMT) develops and offers new platform technologies for cryobiotechnology and future cryobanking. Cryobanks of the future will store biological collections, maintaining a tradition that began with the scientific curiosity chambers of the middle ages and continued with natural science museums, zoos and animal parks. Living cells and small tissue pieces can be stored indefinitely in extremely small volumes. 10 000 mammalian or human cells suspended in a culture medium, can survive cryopreservation without harm and occupy less than a cubic millimetre of storage space, less than that of a pin head. All life processes are suspended at the temperature of liquid nitrogen and constantly changing biosystems can be transformed into rigid bodies; stored for days to decades and be reactivated upon demand.

Industrial biotechnology and clinical applications of cell biology including the rapidly developing cell therapies of regenerative medicine need a robust, efficient and highly safe method of storage. The Fraunhofer-Gesellschaft, as a technology trendsetter, recognised this some year ago and in co-operation with the State of Saarland and the Federal Ministry of Education and Research has developed a wide and unique cryotechnology portfolio. Components of this technology include a miniaturised storage system that permits a sample to be split and part of it to be dispatched without any thawing. Also included are specific devices for freezing and thawing (like the "High Precision Freezer" which is exhibited at the BIOTECHNICA) and cryobank concepts ranging from laboratory size to large-scale industrial systems.

Data is stored in parallel in a central data bank and also firmly attached to the deep frozen cell samples. This principle and its technological solution deliver the almost complete assurance against sample confusion that is most important in medical applications, especially in an autologous and allogenic cell storage for future cell therapies.
Furthermore, this cryotechnology is supported by the evolutionary and adaptive database and cyrobank supervisory architecture. This new method of specimen and data storage in conjunction with the powerful software package "ChameleonLab" (developed together with the company Evotec Technologies, Hamburg) permits self-optimising laboratory automation. This is one of the technological puzzle pieces, which the Fraunhofer IBMT has developed for future cryobanks of regenerative medical and biotechnology and has also made available to the industry. These methods provide complete, overlapping solutions that are on show at the research and demonstration cryobank EuroCyro of the Fraunhofer IBMT and are essential technical preconditions for safe operation of industrial cryobanks.

Visit us October 18-20, 2005 at the BIOTECHNICA 2005 (Hannover, Germany) in Hall 3 at Stand E 16.

Contact:
Dr. Frank Obergrießer
Tel: +49 (0) 6897 / 9071-90
Fax: +49 (0) 6897 / 9071-99
E-Mail: frank.obergriesser@ibmt.fraunhofer.de
Weitere Informationen: http://www.ibmt.fraunhofer.de/ibmt3kryoforschungsbank_e.html http://www.eurocryo.de http://www.ibmt.fraunhofer.de
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